Microglia Response Varies by Sex with PLX3397 Inhibition
New research reveals significant sex-based differences in how adult male and female microglia respond to the enzyme inhibitor PLX3397, a common tool in microglial research. In contrast to male microglia that show expected depletion after treatment, female microglia employ alternative signaling pathways leading to increased survival. These findings highlight the necessity of sex-specific research in … Read more