The Forgotten Proteins: Disordered Structures Now Mainstream
For decades, structural biologists struggled with shoddy data, often finding that proteins wouldn’t show up correctly on their structures. Joel Sussman, a former head of the Protein Data Bank, recalls his first discovery of an intrinsically disordered protein in the 1990s. The mistake was laughable: “Oh, Joel, you’re not a very good biochemist,” he joked. … Read more