A recent study published in JAMA Network Open has found that individuals with a history of upper gastrointestinal (GI) damage have a 76% higher risk of developing Parkinson’s disease. The research, led by investigators at Beth Israel Deaconess Medical Center, suggests that conditions like gastroesophageal reflux disease (GERD), peptic ulcers, and non-steroidal anti-inflammatory drug (NSAID) use may increase the risk of this neurodegenerative disorder.
The study analyzed data from an electronic database covering a representation of urban academic centers, outpatient clinics, and community hospitals in the greater Boston area. Researchers identified a cohort of patients with no history of Parkinson’s disease who underwent upper endoscopy between 2000 and 2005. Patients with mucosal damage were matched in a 1:3 ratio with patients without mucosal damage.
The results showed that among patients with mucosal damage, the risk of developing Parkinson’s disease was significantly higher compared to those without mucosal damage. The study’s findings highlight the importance of heightened monitoring for patients with upper GI damage to identify potential early signs of Parkinson’s disease.
Lead author Dr. Jocelyn Chang noted, “NSAID use is so widespread—from back pain to headaches—and with peptic ulcers globally affecting upwards of 8 million people, understanding the path from mucosal damage to Parkinson’s disease pathology may prove crucial to early recognition of risk as well as potential intervention.”
This research adds to our understanding of the complex relationship between gut health and neurodegenerative diseases like Parkinson’s. Further studies are needed to fully elucidate the mechanisms underlying this association and to develop effective strategies for early detection and prevention of Parkinson’s disease.
Source: https://neurosciencenews.com/gi-damage-parkinsons-27629/