Research suggests that menopause may not provide protection against Alzheimer’s disease as previously thought. Instead, a new study reveals that women with better-quality high-density lipoprotein (HDL) particles during midlife are more likely to experience better cognitive health in later years.
According to the study published by researchers at the University of Pittsburgh, larger HDL particles may not support cognitive health as effectively as smaller ones. Women who had more phospholipid-rich particles and smaller HDL particles were found to maintain better memory over time. This discovery adds to evidence that lifestyle changes can improve brain health.
The study’s findings imply that women can take steps to protect their brains even in their 40s, such as incorporating physical activity, maintaining a healthy weight, and quitting smoking. While higher levels of HDL-C may not be protective against Alzheimer’s disease, these modifiable risk factors can help mitigate the risk of cognitive decline.
Researchers measured HDL particle size, composition, and functioning in 503 midlife women from the Study of Women’s Health Across the Nation (SWAN) HDL ancillary study. The results showed that larger HDL particles decreased in function over time, while those with more phospholipid-rich particles maintained better cognitive health.
The study’s lead author, Samar R. El Khoudary, notes that even small changes in lifestyle can have a positive impact on brain health. By adopting healthy habits, women can potentially reduce their risk of Alzheimer’s disease and other cognitive decline.
Source: https://neurosciencenews.com/hdl-cholesterol-alzheimers-27844/