The American Cancer Society (ACS) has released its annual report on cancer facts and trends, Cancer Statistics 2025. According to the new findings, the cancer mortality rate declined by 34% from 1991 to 2022 in the United States, averting approximately 4.5 million deaths. However, this progress is being jeopardized by increasing incidence rates for many types of cancer, particularly among women and younger adults.
The report highlights a shift in the burden of disease from men to women, with incidence rates in women 50-64 years of age surpassing those in men. Lung cancer is now higher in women than in men among people under 65 years old. The ACS projects that there will be an estimated 2,041,910 new cancer diagnoses in the US and 618,120 cancer deaths in 2025.
The report also highlights lagging progress against pancreatic cancer, which is the third leading cause of cancer death in the US. Incidence rates are increasing, with a five-year survival rate of just 8% for people diagnosed with pancreatic exocrine tumors.
Despite overall declines in cancer mortality, death rates are rising for cancers such as oral cavity, pancreas, uterine corpus, and liver (female). Alarming inequalities in cancer mortality persist, with Native American people facing higher rates of kidney, liver, stomach, and cervical cancers compared to White people. Black people are also more likely to die from certain types of cancer.
The ACS is working to advance efforts to aid in the discovery of new treatments for cancer patients and care for survivors. The organization is currently financing over $450 million in grants to scientists, with a goal of finding answers that help save lives.
Source: https://pressroom.cancer.org/2025CancerFactsandFigures