High-potency cannabis has been found to leave a distinct mark on DNA, according to a study published in Molecular Psychiatry. Researchers analyzed DNA methylation patterns in 682 participants and discovered that frequent users of high-potency cannabis experience changes in genes related to mitochondrial and immune function.
The study, led by Dr. Emma Dempster, aimed to understand the biological impact of cannabis use on mental health. The researchers found that frequent users of high-potency cannabis had altered DNA methylation patterns, particularly affecting genes involved in energy and immune response. These findings suggest that DNA blood tests could potentially help identify individuals at risk of developing psychosis due to cannabis use.
The study’s results also highlight the importance of understanding the effects of cannabis on mental health. Dr. Dempster noted that “DNA methylation bridges the gap between genetics and environmental factors, allowing external influences like substance use to impact gene activity.” The researchers’ findings provide valuable insights into how cannabis use may influence mental health through biological pathways.
The study’s participants were divided into two groups: those who had experienced a first episode of psychosis and those who had never experienced psychosis. The results showed that frequent users of high-potency cannabis had unique epigenetic changes compared to infrequent users, suggesting potential for DNA blood tests to identify at-risk individuals.
As the prevalence of cannabis use increases, particularly among young people, it is essential to better understand its impact on mental health. The study’s findings emphasize the need for further research into the biological effects of cannabis and potential preventative strategies for individuals at risk of developing psychosis.
Source: https://medicalxpress.com/news/2024-10-high-potency-cannabis-epigenetic.html