Researchers at Kumamoto University have made a groundbreaking discovery that sheds light on the inflammatory process linked to aging, known as the senescence-associated secretory phenotype (SASP). The study reveals that blocking ATP-citrate lyase (ACLY), an enzyme involved in converting citrate to acetyl-CoA, can reduce inflammation-related gene expression in aging cells.
The researchers found that ACLY plays a critical role in activating SASP by modifying histones and allowing the chromatin reader BRD4 to activate inflammatory genes. By targeting the ACLY-BRD4 pathway, they were able to suppress chronic inflammation in aged mice, offering a promising new strategy for extending healthy lifespans.
The discovery opens up new avenues for developing treatments that specifically target the harmful aspects of aging cells without removing them. This breakthrough could lead to therapies that promote longer, healthier lives by controlling cellular aging and reducing age-related diseases such as dementia, diabetes, and atherosclerosis.
The study’s findings are significant, particularly given Japan’s rapidly growing aging population. The researchers’ discovery highlights the importance of understanding the underlying mechanisms of inflammation and aging, and their work has the potential to revolutionize the way we approach age-related diseases.
Source: https://neurosciencenews.com/acyl-inflammation-cell-aging-27885/