Scientists have found that specific bacterial communities in the mouth could act as an early warning system for cognitive decline, with some bacteria linked to better brain function while others may contribute to cognitive issues. A study published in PNAS Nexus identified two key bacterial groups: Neisseria and Haemophilus were associated with improved cognitive performance in older adults with mild cognitive impairment (MCI), possibly due to their link with nitrite, a beneficial molecule for brain health. Conversely, bacteria like Prevotella intermedia were more prevalent among individuals carrying the APOE4 gene, a risk factor for Alzheimer’s disease.
This research suggests that maintaining oral health may help identify or predict cognitive decline, particularly in those at genetic risk. Future studies could explore interventions to support brain function through probiotics or dietary changes, offering new avenues for early prevention of cognitive issues. The study involved 120 participants from the PROTECT cohort, funded by several organizations including the National Institute for Health and Care Research and the Wellcome Trust.
The findings emphasize that understanding the role of oral bacteria in brain health could lead to significant implications for managing cognitive decline in older adults.
Source: https://scienceblog.com/553414/your-mouth-bacteria-may-predict-your-dementia-risk-study-shows