GLP-1 weight-loss drugs like Wegovy and Ozempic are facing growing concerns over their side effects and high cost. As more clinicians warn patients about the potential risks, researchers are calling for a closer look at the long-term effects of these medications.
The drugs, which have been shown to be effective in treating obesity, have also been linked to lower rates of heart attacks, stroke, some cancers, and even Alzheimer’s disease. However, the high cost of the brand-name drugs and uneven insurance coverage are creating barriers for many patients who want to use them.
“Everybody just thinks it’s this miracle fix,” said Ethan Lazarus, an obesity medicine physician. “They’re not perfect, and the GLP-1s are only going to work as long as you take them, and they’re expensive, and there can be side effects.”
Studies have shown that many patients drop off these medications within two years due to cost, periodic shortages, and side effects like severe GI distress. The discontinuation of these medications can also lead to “weight cycling,” or the regaining of lost weight, which can negatively impact metabolic health.
The FDA has warned about risks associated with unapproved versions of GLP-1s that aren’t assessed for safety and effectiveness. HHS Secretary-designate Robert F. Kennedy Jr. has also emphasized the need for lifestyle changes and healthier eating habits.
Despite these concerns, researchers are working to better understand the potential harms associated with going on and off these medications. Some studies have shown that coaching and monitoring patients who are taking GLP-1s can lead to improved adherence and outcomes.
As the demand for these medications continues to rise, companies like Knownwell are compiling data that show a connection between coaching and better patient outcomes. With new oral versions of the drugs in development, prices may come down and indications expand, potentially making these medications more tolerable. However, experts warn that the current market is largely unregulated, creating an “unfortunate” situation for patients’ health.
Source: https://www.axios.com/2025/02/11/ozempic-weight-loss-drugs-side-effects