Alzheimer’s disease is a devastating reality for millions worldwide, with hundreds of millions of families searching for a breakthrough cure. However, a recent investigative book reveals a shocking scandal that has tarnished the scientific community.
According to the book “Doctored” by Charles Piller, decades of research into Alzheimer’s was built on false premises. The amyloid hypothesis, which dominated the field for years, suggested that clumps of sticky protein called amyloid plaques were responsible for the disease’s symptoms. Billions of dollars in funding was spent on new drugs based on this theory.
However, investigations have revealed that key images used to support the research were likely Photoshopped to fit the hypothesis. The 2006 paper from the University of Minnesota, which became one of the most cited in the field, has been retracted after allegations of fabrication. Several other papers built around the same findings have also been discredited.
The implications are severe: years of work and funding may have been based on fraudulent evidence. The scale of harm caused is incalculable, as scientists may have set back the quest to find treatments for Alzheimer’s by many years.
While “Doctored” raises uncomfortable questions about the integrity of scientific research, it also sheds light on the need for accountability in the medical community. Piller’s meticulous and patient reporting makes for a compelling read, despite some repetition in his pen portraits of key figures. This book is essential reading for those making decisions on future research funding.
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Source: https://www.theguardian.com/books/2025/feb/20/doctored-by-charles-piller-review-the-scandal-that-derailed-alzheimers-research