Researchers at the University of Oxford have found promising evidence that diabetes medications could be used to treat a range of mental health disorders, including dementia and substance use disorders. A study published in Nature Mental Health reviewed data from preclinical and clinical studies on glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, commonly used for diabetes and obesity.
The study found that these medications may improve cognition, reduce addictive behavior, and alleviate depression and anxiety. However, more research is needed to fully understand their efficacy and safety profile, particularly with long-term use.
At present, there is no clinical recommendation for using GLP-1RAs in mental illness. Nevertheless, the findings suggest potential for further investigation into these medications’ effects on mental health.
The study’s authors hope that future collaborations between endocrinologists, psychiatrists, and neuroscientists will develop integrated treatment approaches to address the needs of patients with complex illnesses.
Source: https://medicalxpress.com/news/2025-02-diabetes-drugs-mental-health-treatment.html