A new study published in Cell Host & Microbe reveals that the SARS-CoV-2 spike protein can persist in the brain’s protective layers and skull bone marrow for up to four years after infection, potentially driving long COVID’s neurological symptoms. Researchers used advanced imaging techniques to detect elevated spike protein levels in these regions.
The presence of the spike protein in these areas was found to trigger chronic inflammation and increase the risk of neurodegenerative diseases. However, mRNA COVID-19 vaccines were shown to reduce spike protein accumulation by 50%, although residual protein may still pose risks.
The study’s findings highlight the need for new therapies and early diagnostic tools to address long-term effects on brain health. The researchers also discovered that injection of spike protein alone can induce neuroinflammation and exacerbate stroke and traumatic brain injury outcomes in mouse models.
While vaccination reduced spike protein accumulation, the persistence of the protein after infection remains a concern. The study’s authors suggest that persistent spike protein at the brain borders may contribute to lasting neurological sequelae of COVID-19.
The research has significant implications for global public health and healthcare systems worldwide, as an estimated 400 million individuals may carry significant amounts of spike protein due to long COVID.
Source: https://neurosciencenews.com/long-covid-spike-protein-brain-28156