Aging is a complex and multifaceted process affecting multiple organ systems, leading to physiological decline and increased disease risk. Despite improvements in life expectancy, extending health span remains a challenge. Recent research highlights the role of nutrition, gut microbiota, and bioactive compounds in modulating aging by preserving functional health.
Studies have shown that dietary interventions and nutraceuticals can provide innovative solutions for promoting healthy aging and reducing age-related disease burden. For example, certain probiotics, such as Lacticaseibacillus paracasei (LC86), have been found to alleviate sarcopenia and cognitive decline in senescence-accelerated mouse models.
Bioactive compounds like eggshell membrane (ESM) have also been shown to promote joint health, wound healing, and skin integrity. ESM hydrolysates retain anti-inflammatory properties post-digestion and may alleviate joint pain and stiffness. Furthermore, recent findings suggest that ESM consumption increases gut microbiota diversity, alters composition, and reduces inflammation markers in mice and human studies.
Phytonutrients have also been found to modulate specific hallmarks of aging. A comprehensive review proposes a paradigm shift towards including specific phytonutrients in a preventive nutritional strategy based on their capacity to preserve functional health.
While the evidence is promising, further research is necessary to translate these findings into practical applications for extending health span and improving quality of life. The authors emphasize the importance of continued investigation into the complex interplay between nutrition, gut microbiota, and bioactive compounds in modulating aging.
Source: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1578242/abstract