Herpes simplex virus-1 (HSV-1) is a common virus affecting millions worldwide. According to the World Health Organization, nearly two-thirds of people under 50 may be infected. While most symptoms are mild, HSV-1 can also cause serious and chronic issues when it affects the eye or nervous system.
New research has discovered that nasal herpes infections can lead to anxiety, cognitive problems, and motor impairment. This is because pathogens can directly reach the brain through tears, bypassing other areas of the body. Researchers believe this neurological impact may be more severe than previously thought.
Studies showed that HSV-1 harnesses an enzyme called heparanase in host cells, leading to behavioral symptoms. When this enzyme was deactivated, animal models exhibited fewer behavioral problems after infection. The researchers suggest heparanase is linked to the neurological symptoms of HSV-1 infections.
Animals with HSV-1 infections displayed significant neuronal damage and inflammation within days, followed by long-term impairments in motor coordination and memory. Symptoms of anxiety also persisted for months or even decades. Dr. Deepak Shukla notes that nerve damage from intranasal infection routes can have lasting effects, highlighting the need to prevent and treat HSV-1 infections.
These findings underscore the importance of addressing this widespread issue, which is likely carried by billions of people worldwide.
Source: https://www.labroots.com/trending/cell-and-molecular-biology/28678/common-viral-infection-cause-neurological-symptoms