Researchers have identified a potential early indicator for Alzheimer’s disease in the retina. A study published in Alzheimer’s & Dementia found that changes in retinal structure and function, particularly those associated with the APOE4 gene, can be linked to visual processing deficits and neurodegenerative symptoms.
The research team used advanced imaging techniques to assess retinal thickness and electrical activity in mice with the genetic variant. They observed significant alterations compared to control groups, mirroring aspects of Alzheimer’s pathology.
These findings support the use of retinal changes as early biomarkers for Alzheimer’s diagnosis, which could improve patient outcomes and quality of life. The study suggests that retinal imaging may be a non-invasive method to detect early neural changes in Alzheimer’s disease.
According to Ashay Bhatwadekar, associate professor of ophthalmology, “The eye is a window to the brain reflecting changes associated with neurodegenerative conditions such as Alzheimer’s disease.” The study provides new insights into using retinal changes to aid in diagnosis and treatment of Alzheimer’s disease.
Source: https://www.futurity.org/retina-changes-alzheimers-early-warning-3272932