Researchers have long sought to understand why some people with high-risk Parkinson’s gene variants develop the disease, while others do not. A new study from Northwestern University has identified a set of 16 Commander proteins that regulate lysosomal function and influence Parkinson’s disease development. Using CRISPR interference to screen the entire genome, scientists found that loss-of-function variants in these genes increase Parkinson’s disease risk. The findings clarify disease mechanisms and introduce new targets for potential therapies, offering hope for developing treatments that can restore lysosomal health and slow neurodegeneration.
Source: https://neurosciencenews.com/commander-gene-parkinsons-28612