A new study published in JAMA Network Open has found that colorectal and pancreatic adenocarcinoma incidence rates have risen significantly among young adults over the past two decades. The study, conducted by researchers at Robert Wood Johnson University Hospital and Rutgers Robert Wood Johnson Medical School, analyzed data from 275,273 cases of pancreatic adenocarcinoma and 215,200 cases of colorectal adenocarcinoma between 2000 and 2021.
The findings suggest that the highest annual percentage change for both cancers occurred in the youngest age group of 15-34. For pancreas adenocarcinoma, this age group showed a 4.35% increase, compared to 1.54% for age groups 35-54 and 1.74% for those over 55. Similarly, for colorectal adenocarcinoma, the youngest age group saw a 1.75% increase, while age groups 35-54 showed a 0.78% increase, and those over 55 had a -3.31% decrease.
The study’s lead author, Arvind Bussetty, MD, notes that clinicians should be aware of this trend in younger age groups, as pancreatic cancer is often viewed as a disease seen in older patients. He advises providers to be vigilant when diagnosing pancreatic adenocarcinoma among young patients presenting with abdominal pain and other concerning symptoms.
The study did not identify the root causes for the increase in cases but suggests that factors such as dietary changes, stress, and environmental factors may play a role. Dr. Bussetty emphasizes the importance of regular screenings, particularly for high-risk individuals with family histories or genetic predispositions to pancreatic cancer.
According to experts, younger patients with a family history of pancreatic cancer should consult a gastroenterologist, while those who are average risk should undergo guideline-recommended screening colonoscopy at age 45. The study’s findings highlight the need for increased awareness and vigilance among clinicians when diagnosing these cancers in young adults.
Source: https://www.rwjbh.org/blog/2025/april/robert-wood-johnson-university-hospital-and-rutg