Borrelia burgdorferi, the bacterium that causes Lyme disease, has been found to have a unique property that allows its peptidoglycan to persist in discrete tissues and trigger systemic responses similar to those experienced in chronic illnesses. This discovery provides new insights into the mechanisms of Lyme disease and potential therapeutic targets for its treatment.
Researchers have identified that the persistent peptidoglycan can cause inflammation and immune system activation, leading to symptoms such as fatigue, joint pain, and cognitive impairment. These findings suggest that the infection may not be limited to the initial stages, but rather can lead to long-term consequences for the host.
The study’s authors hope that this research will contribute to a better understanding of Lyme disease and its effects on the human body. Further investigation is needed to explore the potential therapeutic strategies that could target the persistent peptidoglycan and alleviate symptoms in patients with chronic Lyme disease.
Source: https://www.science.org/doi/10.1126/scitranslmed.adr2955