Researchers at the University of Texas Health Science Center at San Antonio have discovered a link between high cortisol levels in menopausal women and an increased risk of Alzheimer’s disease. The study highlights the importance of considering sex and hormonal status in understanding the development of the disease.
Cortisol, often referred to as the “stress hormone,” plays a key role in the body’s response to stress. When elevated, it helps prepare the body for immediate action by increasing blood sugar and enhancing brain function. However, prolonged activation of the stress response and excessive cortisol exposure can lead to various health problems.
The study found that menopausal women with high cortisol levels were more susceptible to Alzheimer’s disease. This association was not observed in men. Researchers suggest that reducing stress and hormonal interventions could be effective in slowing down or preventing the disease in at-risk women.
Mutations in hormones with anti-inflammatory effects also signaled increased susceptibility to Alzheimer’s. Higher blood cortisol levels were linked to a greater risk of developing the disease, but early identification of risk factors is crucial for effective interventions. The study offers hope that interventions can still be effective if implemented at an earlier stage of Alzheimer’s disease.
Source: https://www.tpr.org/bioscience-medicine/2025-05-16/for-menopausal-women-high-levels-of-cortisol-associated-with-stress-linked-to-alzheimers-disease