Researchers have made significant strides in understanding post-traumatic stress disorder (PTSD) by examining brain cells at a single-cell level. A study published in Nature found distinct genetic alterations that may drive the disorder, particularly in the dorsolateral prefrontal cortex, a region tied to emotional regulation.
The study, led by Matthew Girgenti, analyzed individual cell nuclei from brains with PTSD, major depressive disorder (MDD), and control brains. The findings revealed impaired signaling in inhibitory neurons in PTSD, which may contribute to hyperarousal symptoms. Additionally, the researchers discovered differences in microglial activity between PTSD and MDD, as well as vascular endothelial cells that showed signs of dysfunction.
The study identified gene pathways that could be targeted with precision drugs developed specifically for PTSD. The researchers hope that these insights will help lead to better therapies for the disorder. Future studies plan to examine other regions of the brain involved in PTSD pathology, such as the hypothalamus.
This breakthrough research highlights the importance of understanding the molecular mechanisms underlying PTSD and promises new avenues for treatment.
Source: https://neurosciencenews.com/ptsd-brain-cell-29313