A recent study sheds light on the lesser-known extracellular matrix (ECM) and its potential impact on aging hearts. The ECM plays a crucial role in supporting cell structure, preventing tissue adhesion, enhancing communication between cells, and facilitating wound healing.
As we age, organs and systems slow down, affecting the heart’s efficiency. Researchers investigated the ECM’s effects on cardiac function and discovered that changes in this environment may contribute to the decline in heart health with age. The study used a novel model, DECellularized In Situ Polyacrylamide Hydrogel-ECM hybrid (DECIPHER), which allowed researchers to independently control stiffness and biochemical signals presented to cells.
The results showed that young cell signaling outweighed the negative effects of stiff ECM, while young cells placed on aged ECM showed signs of dysfunction. This suggests that the biochemical environment around aged heart cells is more important than stiffness. Medical experts emphasize that targeting the extracellular environment may hold promise for slowing or reversing age-related cardiac dysfunction.
While human studies are needed to validate these findings, lifestyle changes can support heart health. Experts recommend regular aerobic exercise, a healthy dietary pattern, quitting smoking, adequate sleep, weight management, stress reduction, and moderate alcohol intake. By adopting these evidence-based strategies, individuals can reduce their risk of heart disease and promote overall well-being.
Source: https://www.medicalnewstoday.com/articles/scientists-find-novel-way-slow-reverse-aging-heart