A recent study from Queen Mary University of London reveals how caffeine activates AMPK, a key cellular fuel sensor that helps cells cope with stress and energy shortages. This activation could explain why coffee is linked to better health and longer life.
Caffeine has long been associated with potential health benefits, including reduced risk of age-related diseases. However, its mechanisms inside cells remained unclear until now. Researchers studied fission yeast, a single-celled organism similar to human cells, and discovered that caffeine affects aging by tapping into an ancient cellular energy system.
In contrast to previous findings suggesting caffeine’s role in activating the growth regulator TOR, this new study reveals that caffeine activates AMPK, a cellular fuel gauge conserved in yeast and humans. When cells are low on energy, AMPK kicks in to help them cope. Caffeine’s effect on AMPK influences how cells grow, repair their DNA, and respond to stress – all tied to aging and disease.
The study’s results provide insight into why caffeine might be beneficial for health and longevity. Furthermore, this discovery opens up possibilities for future research into triggering these effects through diet, lifestyle, or new medicines. So, the next time you reach for your coffee, you may be giving your cells a helping hand that could contribute to better overall well-being.
Source: https://www.sciencedaily.com/releases/2025/06/250625075024.htm