Gabapentin, a commonly prescribed anticonvulsant for chronic pain, may be linked to an increased risk of developing dementia and cognitive impairment, according to a new study.
Researchers from Case Western Reserve University School of Medicine found that adults prescribed gabapentin for chronic low back pain had a 29% higher risk of developing dementia and an 85% higher risk of mild cognitive impairment within 10 years compared to those with back pain who were not prescribed the drug.
However, experts cautioning interpretation of the study, citing potential confounding variables and the lack of control for physical activity levels.
The study used the TriNetX national database to analyze 26,416 gabapentin users and an equal number of nonusers. The findings suggest that gabapentin prescription is associated with a higher incidence of dementia and cognitive impairment in both elderly and nonelderly groups.
Specifically, patients aged 35-49 who were prescribed gabapentin had a significantly increased likelihood of developing dementia and cognitive impairment, as did those in the 50-64 age group. The risk further increased with prescription frequency.
While the study provides valuable insights, experts emphasize the need for caution when interpreting its findings due to potential limitations and confounding variables.
Source: https://www.medscape.com/viewarticle/does-gabapentin-raise-dementia-risk-2025a1000id3