Research from Harvard University and Mass General Brigham has found that a Mediterranean diet can significantly reduce the risk of Alzheimer’s disease, even in individuals with two copies of the APOE4 gene, which is the strongest known genetic risk factor for developing the disease.
The study analyzed data from 4,215 women over 30 years and found that those who followed a strictly Mediterranean diet experienced reduced dementia risk. The diet consists of fish, legumes, nuts, vegetables, and healthy fats.
Interestingly, people with two copies of the APOE4 gene responded most positively to the Mediterranean diet compared to those with one or no copies. This was due to changes in blood biomarkers, which included lower inflammation, better blood vessel health, improved insulin sensitivity, and decreased levels of amyloid plaques that contribute to Alzheimer’s-related cognitive decline.
The study suggests that dietary strategies, specifically the Mediterranean diet, could help reduce the risk of cognitive decline and stave off dementia by broadly influencing key metabolic pathways. The researchers emphasized that this recommendation applies broadly but may be even more important for individuals at a higher genetic risk.
While the study found significant benefits, critics argue that few average people can afford the foods required for the Mediterranean diet due to rising costs.
Source: https://www.dailymail.co.uk/health/article-15032527/The-science-backed-diet-lower-dementia-risk-you-Alzheimers-gene.html