Intense mental exercise may help counteract the effects of aging, according to a new study. Researchers found that cognitive training increased levels of acetylcholine, a chemical messenger linked to decision-making and memory, in older adults. This boost was observed in areas of the brain responsible for attention, processing speed, and memory, including the anterior cingulate cortex and hippocampus.
The study involved 92 healthy individuals aged 65+, who underwent either 10 weeks of mental exercises or played video games like Solitaire and Candy Crush for comparison. Those participating in cognitive training showed a 2.3% increase in acetylcholine levels, reversing about 10 years’ worth of age-related decline. This effect was significant, considering the natural decrease of 2.5% per decade.
Neuroscientists believe that such increases in acetylcholine can improve cognitive function, even by small amounts. A cup of coffee can already boost levels enough to enhance attention and reaction time. The findings suggest that hardcore brain training may offer a similar benefit, particularly for those with Alzheimer’s disease.
Source: https://www.npr.org/2025/10/17/nx-s1-5573076/intense-mental-exercise-may-be-able-to-offset-the-effects-of-aging-research-finds