Researchers have found that people in their 80s and 90s with exceptional memories, known as “SuperAgers,” produce twice the number of young neurons as healthy adults and 2.5 times more than those with Alzheimer’s disease. This suggests that the aging brain has the ability to regenerate, providing hope for cognitive preservation.
According to Dr. Tamar Gefen, a study coauthor, SuperAgers’ brains contain more robust support systems in the hippocampus, which nurtures youthful neurons and enhances brain plasticity. The study found that SuperAgers have a unique cellular environment in their hippocampus that supports neurogenesis, the birth of new neurons.
The results show that SuperAgers’ brains are more resilient to cognitive decline, with thicker cortices and fewer tau tangles than people in their 50s and 60s. Additionally, analysis of brain tissue revealed “beautiful” and healthy neurons in the entorhinal cortex, one of the first areas affected by Alzheimer’s disease.
The study suggests that a combination of genetic advantages and lifestyle choices may contribute to SuperAgers’ exceptional cognitive abilities. Dr. Richard Isaacson notes that research has shown that brain-healthy habits such as diet, exercise, stress reduction, and sleep optimization can also promote neurogenesis and reduce the risk of Alzheimer’s.
The findings offer new insights into the aging brain and its potential for regeneration, providing hope for individuals looking to maintain their cognitive function as they age.
Source: https://edition.cnn.com/2026/02/25/health/superagers-brain-plasticity-neurogenesis-wellness