Researchers from the University of California, San Diego, have used artificial intelligence to make a groundbreaking discovery about Alzheimer’s disease. They identified a gene called phosphoglycerate dehydrogenase (PHGDH) that may be contributing to the development of the disease. The team found that PHGDH was interacting with other genes in brain cells, disrupting the brain’s ability to regulate inflammation and clear out waste.
AI modeling revealed a previously hidden function of PHGDH: it acts as a “switch” for other genes, turning them on and off. This interaction led to the development of a potential therapeutic candidate called NCT-503. The molecule was able to bind to PHGDH and stop its unauthorized gene-switching, showing promise in mouse models of Alzheimer’s disease.
Treated mice showed improvements in memory and anxiety tests, demonstrating the efficacy of NCT-503. Crucially, the molecule can pass through the blood-brain barrier, allowing it to access neurons and their associated cells, making oral administration a possibility.
While more research is needed, this study brings us closer to developing new treatments for Alzheimer’s disease. The discovery highlights the potential of AI in unlocking therapeutic solutions for complex diseases like Alzheimer’s.
Source: https://www.sciencealert.com/ai-discovers-suspected-trigger-of-alzheimers-and-maybe-a-treatment