The battle against Alzheimer’s has taken a surprising turn. Long-held theories are being challenged, with emerging research pointing to the possibility that the disease is actually an immune system disorder.
A 2006 study published in Nature, which suggested beta-amyloid protein was the culprit behind Alzheimer’s, has been re-examined in light of new findings. However, a recent paper in Science suggests that this data may have been fabricated.
The FDA’s approval of aducanumab, a drug targeting beta-amyloid, adds to the controversy due to incomplete and inconsistent evidence for its effectiveness. The debate raises questions about why millions are still waiting for a successful Alzheimer’s cure.
Researchers at the Krembil Brain Institute propose that beta-amyloid plays a crucial role in the brain’s immune system, helping protect against threats. However, its actions can sometimes backfire, leading to unintended harm and progressive brain cell function loss.
This new theory suggests that Alzheimer’s disease can be seen under the umbrella of autoimmune diseases where the body attacks itself. Although traditional therapies may not work, researchers are hopeful that focusing on other immune-regulating pathways could lead to effective treatment approaches.
As the search for an Alzheimer’s cure continues, it’s essential to consider fresh perspectives and innovative ideas. With over 50 million people worldwide affected by dementia, a better understanding of its causes – including its possible links to the immune system – is crucial.
Source: https://www.earth.com/news/alzheimers-may-not-be-a-brain-disease/