A recent study presented at the European Heart Rhythm Association’s 2025 Congress found that antidepressants may be associated with an increased risk of heart-related deaths. Researchers analyzed data from Danish residents between the ages of 18 and 90 who died in 2010, comparing those who took antidepressants to those who didn’t.
The study found a significant link between antidepressant use and sudden cardiac death, particularly among individuals exposed to the medication for six years or more. Those taking antidepressants for one to five years had a 56% higher risk of sudden cardiac death, while those using it for six or more years had a 2.2 times higher risk.
The study’s lead author notes that exposure time to antidepressants may be associated with increased heart health risks due to the potential for underlying illness or lifestyle factors. Researchers emphasize that further investigation is needed to determine the specific reasons behind this association.
It’s worth noting that while antidepressants are generally considered safer than older classes, they can still interact with other medications and come with side effects. It’s essential to consult a doctor to weigh the benefits and risks of taking antidepressants.
For context, approximately 20 million American adults and 3.7 million kids aged 12-17 live with depression, with many relying on antidepressants as a vital tool for managing their condition.
Source: https://fortune.com/well/article/medication-antidepressants-ssri-risk-cardiac-death