A new study has found that antidepressants provide little to no benefit in relieving low back pain and sciatica, despite their common prescription. Researchers from Neuroscience Research Australia and the University of New South Wales reviewed existing research on 2,932 participants with non-specific low back pain or spine-related leg pain. They analyzed data on seven classes of antidepressants, including serotonin and norepinephrine reuptake inhibitors (SNRIs), selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and tetracyclic antidepressants.
The study found that antidepressants may reduce pain within three to four months but have a small effect, making it difficult for patients to notice. They also come with an increased risk of side effects. The researchers conclude that more research is needed on the long-term benefits and harms of using antidepressants for low back pain and sciatica.
The study highlights the need for large, high-quality clinical trials to inform treatment decisions. It emphasizes the importance of informed discussions between patients and healthcare providers about the likely benefits and risks of antidepressant medication for low back pain and sciatica.
Source: https://newatlas.com/health-wellbeing/antidepressants-low-back-pain-trivial