A recent study has shed new light on the link between gut health and Parkinson’s disease, suggesting that supplementing with riboflavin (vitamin B2) and biotin (vitamin B7) may help alleviate symptoms. Researchers at Nagoya University found that people with Parkinson’s disease have altered gut bacteria communities that are associated with decreased levels of these essential vitamins.
The study, which analyzed fecal samples from 94 patients with Parkinson’s disease and 73 healthy controls in Japan, discovered that changes in the gut microbiome were linked to lower levels of riboflavin and biotin. These nutrients play a crucial role in synthesizing short-chain fatty acids (SCFAs) and polyamines, which help maintain a healthy intestinal mucus layer.
Deficiencies in these molecules have been observed in people with Parkinson’s disease, leading to increased intestinal permeability and exposure to toxins such as cleaning chemicals and pesticides. This can trigger the production of α-synuclein fibrils, which contribute to motor and dementia symptoms.
However, previous research has shown that high doses of riboflavin can help recover motor functions in patients who eliminated red meat from their diets. The Nagoya University researchers propose that similar supplementation with vitamin B may prevent some damage and suggest that maintaining a healthy gut microbiome could be protective.
While more research is needed to confirm the findings, the study’s authors emphasize that each individual’s experience with Parkinson’s disease may vary. Further analysis of patients’ gut microbiota or fecal metabolites could help identify specific deficiencies and guide treatment decisions.
Source: https://www.sciencealert.com/parkinsons-gut-bacteria-link-suggests-an-unexpected-simple-treatment