Scientists have made a groundbreaking discovery that could lead to a single treatment for multiple incurable diseases, including HIV, Zika, herpes, and RSV. Researchers identified compounds that activate the host’s natural defense pathway, which shuts down protein production when a virus infects cells. This approach targets the integrated stress response pathway, amplifying the body’s response to fight viral infections.
Developed by a team of researchers, the novel screening technique tested nearly 400,000 chemical compounds to find promising candidates. The discovered molecules successfully helped human cells fend off RSV, herpes, and Zika virus infections in tests. IBX-200, one of the compounds, demonstrated effectiveness in mice, reducing viral load and symptoms of herpes.
The findings are significant because the compounds only activate when a virus triggers the stress response, with no effect on healthy cells. The team is excited about this breakthrough, which could lead to broad-spectrum antivirals developed through harnessing the host’s natural defense mechanism. Further testing against multiple viruses is planned to bring this treatment closer to clinical trials.
Source: https://www.notebookcheck.net/New-discovery-may-bring-a-one-for-all-treatment-for-incurable-diseases-like-HIV-Zika-herpes-and-RSV.1058035.0.html