Scientists at the University of California – San Francisco (UCSF) have made a groundbreaking discovery that could lead to new treatments for Alzheimer’s disease. Researchers identified a key receptor, ADGRG1, which helps microglia, immune cells in the brain, digest toxic amyloid beta plaques. The presence of this receptor enables microglia to break down these proteins effectively, reducing the risk of memory loss and brain damage.
The study found that when microglia lack the receptor, plaque buildup accelerates, leading to severe cognitive impairment and neurodegeneration. In contrast, individuals with mild Alzheimer’s had abundant ADGRG1 in their microglia, suggesting a protective effect. The discovery opens up new avenues for therapies targeting this receptor, which belongs to a drug-friendly family of receptors.
The researchers used a mouse model of Alzheimer’s disease and found that the loss of ADGRG1 led to rapid plaque buildup, neurodegeneration, and problems with learning and memory. This study provides hope for developing new treatments that can enhance brain immunity and protect against Alzheimer’s in more people.
Source: https://www.sciencedaily.com/releases/2025/07/250726234423.htm