Researchers at Mayo Clinic have made a groundbreaking discovery using aptamers, tiny DNA molecules that can selectively tag senescent cells, also known as “zombie cells.” These cells stop multiplying but fail to clear themselves from the body, contributing to various diseases, including cancer, Alzheimer’s disease, and aging. The team identified rare aptamers capable of binding to unique surface proteins on senescent cells in mouse tissue, marking a significant step towards developing new treatments.
The idea for this project originated from a chance conversation between two graduate students, Keenan Pearson and Sarah Jachim, who were studying different aspects of cellular biology. They joined forces with their advisors and researchers Nathan LeBrasseur and Darren Baker to explore the potential of aptamers in detecting senescent cells. The team’s innovative approach uses advanced microscopy techniques and tissue types to reveal new clues about the biology of these “zombie” cells.
The discovery has far-reaching implications for human health, as it could lead to the development of targeted treatments that deliver medications directly to senescent cells. While more work is needed to refine this technology, the Mayo Clinic researchers are optimistic about its potential to revolutionize our understanding and treatment of age-related diseases.
Source: https://www.sciencedaily.com/releases/2025/12/251213032625.htm