Parkinson’s disease is the world’s second most common neurodegenerative disorder, affecting up to 90,000 people in the US each year. The disease gradually destroys dopamine-producing neurons in the brain, leading to motor symptoms such as tremors and rigidity.
Scientists have been exploring an alternative solution: replacing dying dopamine neurons with new ones using stem cells. Two recent studies found that this approach is safe and reduced symptoms in patients with Parkinson’s.
In one study, researchers transplanted nearly three million lab-grown stem cells into the brains of 12 middle-aged patients. The cells were taken from a human embryonic-stem-cell line, which can reproduce indefinitely, making them an unlimited resource. After 18 months, follow-up brain scans found higher levels of dopamine and significant improvements in motor symptoms.
Another study used induced pluripotent stem cells (iPSCs) to create new dopamine neurons from a donor’s skin cells. These cells were transplanted into seven Parkinson’s patients and showed promise by easing motor symptoms for over two years.
While the results are encouraging, both studies have limitations, including the large number of cells involved. Scientists need more evidence to prove the effectiveness of this therapy. Larger trials are underway to test its safety and efficacy in a wider population.
This breakthrough offers new hope for patients with Parkinson’s disease, who currently rely on medications that wear off over time. Further research is needed to develop this treatment into a viable option, but the potential is significant.
Source: https://singularityhub.com/2025/04/17/parkinsons-patients-say-their-symptoms-eased-after-receiving-millions-of-new-brain-cells