Scientists at the University of California San Francisco (UCSF) have discovered a potential cause of aging in the brain. The culprit is ferritin light chain 1 (FTL1), an iron-associated protein linked to impaired cognition.
Researchers studied mice brains over time, comparing genes and proteins in the hippocampus – the region responsible for learning and memory. They found that aged mice had higher levels of FTL1, fewer brain connections, and reduced cognitive abilities.
Increasing FTL1 in young mice led to a decline in brain health, while decreasing it reversed the effects, restoring nerve cell connections and improving memory performance.
The study suggests that stimulating metabolism in hippocampus cells can counteract these effects. Dr. Saul Villeda calls this finding “reversal of impairment,” stating it’s not just about delaying symptoms but also alleviating their worst consequences.
Neurosurgeon Dr. Paul Saphier agrees, noting the connection between protein accumulation and neurodegenerative disorders like Alzheimer’s disease. He sees potential for improving cognition by slowing down FTL1 buildup in the hippocampus.
The study was supported by the National Science Foundation, Bakar Aging Research Institute, and National Institute on Aging.
Source: https://www.foxnews.com/health/aging-brains-could-become-younger-when-key-protein-decreased