A breakthrough in understanding antibodies, proteins that fight bacteria and viruses, may lead to a new way to slow aging. By targeting specific proteins related to the aging process, researchers hope to improve health and extend lifespan.
Normally, our immune systems produce tailored antibodies to combat infections. This precision is now being explored for its potential in treating age-related diseases. Since our bodies already have this technology, scientists are adapting it for medical use.
The first antibody approved was muromonab-CD3 in 1986, designed to suppress the immune system and prevent organ rejection. Today, hundreds of antibodies are used in various treatments, including cancer and pregnancy tests. The latest research focuses on aging itself.
In 2021, researchers used antibodies to guide a deadly drug to aged cells, improving mice’s lifespan. Another study rejuvenated old mice’s skin with subtly different antibodies. These findings suggest that repurposing antibody technology could improve health in older age.
Recent studies have shown promise: targeting IL-11 protein increased inflammation reduction and extended mice’s lifespan by 25%. The anti-IL-11 antibodies are already in human trials, with preliminary results indicating safety. Nobel laureate Greg Winter hopes to benefit from this technology, having experienced the challenges of aging and taking multiple medications. His dream of a convenient antibody treatment may come true by 2025.
Source: https://www.wired.com/story/antibodies-could-soon-help-slow-the-aging-process