Cancer-induced nerve injury plays a significant role in driving chronic inflammation and immune exhaustion, ultimately contributing to resistance to immunotherapy. Researchers at MD Anderson Cancer Center have made a groundbreaking discovery that sheds light on the complex interplay between cancer, neuroscience, and the immune system.
According to the study co-led by Moran Amit, Neil Gross, and Jing Wang, nerve injury triggered by cancer can lead to chronic inflammation, which in turn exhausts the immune system. This exhaustion makes it challenging for the body to mount an effective response against cancer cells treated with immunotherapy.
The finding is considered a significant advance in understanding tumor-neuro-immune dynamics and highlights the importance of investigating the relationship between cancer and neuroscience in developing new treatments that can directly impact clinical practice.
As Dr. Amit notes, “This marks a pivotal moment in our understanding of this complex interaction.”
Source: https://oncodaily.com/voices/cancer-induced-nerve-353134