Cancer survivors, particularly females, experience higher rates of cancer-related fatigue and depression compared to their male counterparts. A recent study presented at the American Association for Cancer Research Annual Meeting 2025 found that female cancer patients are nearly two times more likely to reduce their recreational activities due to these conditions.
According to the study, published in Abstract 4989 / 3, female cancer survivors have a 58% higher likelihood of experiencing depression and a 69% higher likelihood of experiencing cancer-related fatigue compared to males. These findings highlight the importance of targeted interventions to address sex disparities in cancer-related fatigue and depression, ultimately improving quality-of-life among cancer survivors.
The study analyzed data from over 1,500 cancer patients and found that cancer-related fatigue was associated with reduced rates of moderate recreational activities, but not significantly associated with limitations to work-related activities. Depression was also linked to a reduction in recreational activities.
“The findings emphasize the need for tailored interventions such as exercise programs, support groups, and mind-body behavioral techniques to effectively manage fatigue and improve participation in recreational activities,” said Simo Du, MD, MHS, one of the study authors. “These interventions are essential for enhancing quality-of-life among cancer survivors.”
The study’s authors call for special attention to be given to vulnerable groups, highlighting the importance of providing targeted support to help manage cancer-related fatigue and improve participation in recreational activities as a crucial aspect of overall well-being.
Source: https://ascopost.com/news/april-2025/sex-disparities-identified-in-fatigue-and-depression-for-cancer-survivors