Researchers warn clinicians about the potential cardiovascular risks of cannabis use, citing evidence from large-scale studies and observational research. A US study found daily cannabis users had a 49% increased risk for myocardial infarction and a twofold increased risk for stroke compared to non-users. The effect was dose-dependent, with weekly users experiencing a 3% increased likelihood of heart attack and a 5% increased risk for stroke.
The link between cannabinoids and cardiovascular disease is now evident in epidemiological studies, researchers from Stanford reported in a recent paper in Nature Reviews Cardiology. Although the association is still being studied, cardiologists recommend patients avoid cannabis or reduce their use to minimize potential risks.
Studies have found an association between arrhythmia, especially atrial fibrillation, and cannabis use. A study published last year in the European Heart Journal showed the risk for new onset arrhythmia was 0.8% among more than 5000 patients who had filled a cannabis prescription, compared to 0.4% for control participants.
Cannabinoids bind to CB1 receptors in the brain and myocardium, promoting atherosclerotic changes. THC, the primary psychoactive compound in cannabis, may cause inflammation and oxidative stress inside the vasculature. The activation of these receptors can lead to enzyme inhibition that affects the heart’s electrical conduction system.
Cardiologists advise patients who use cannabis about potential long-term cardiovascular side effects. They recommend reducing cannabis use or consuming edible forms instead of smoking to minimize toxin exposure. While there is limited evidence on the safety of cannabis consumption, alternative pain management options may be more suitable for the heart.
Source: https://www.medscape.com/viewarticle/cannabis-interfering-heart-2025a10006c2