College football fans are eagerly awaiting the start of the 2025 season, with several high-profile matchups set to kick off Week 1. Here’s a look at the latest betting lines from FanDuel Sportsbook.
In one of the most anticipated games, Nebraska (-6.5) is favored to take on Cincinnati. The Cornhuskers are looking to revamp their offense under center Dylan Raiola and coach Dana Holgorsen. Meanwhile, Auburn (-2.5) is set to face Baylor, with new head coach Hugh Freeze looking to make an impact after signing Oklahoma transfer Jackson Arnold.
In the Atlantic Coast Conference, Georgia Tech (-3.5) is facing Colorado, while Ohio State (-3.5) takes on Texas in a highly anticipated rematch of the CFP semifinal. Tennessee (-12.5) faces Syracuse, with questions surrounding both teams’ offenses and quarterbacks.
The SEC’s top teams are set to face off in Alabama (-11.5) vs. Florida State and Clemson (-2.5) vs. LSU. The Tigers will test what should be a physical Clemson defensive unit.
In the American Athletic Conference, South Carolina (-9.5) is looking to bounce back from last season with LaNorris Sellers at the helm, while Notre Dame (-1.5) takes on Miami in another intriguing early road game.
The final matchup sees North Carolina (-1.5) facing TCU.
Source: https://www.si.com/fannation/college/cfb-hq/betting/college-football-odds-week-1-2025-games