Researchers at Western University have discovered that individuals with cannabis use disorder (CUD) have elevated dopamine levels in brain regions associated with psychosis, regardless of schizophrenia diagnosis. The study used neuromelanin-sensitive MRI scans to identify areas of excess dopamine activity, visible as darker brain spots.
The findings suggest accelerated dopamine-related aging in the brain, which may explain the rise in cannabis-induced psychosis since legalization. The study highlights the need for greater public awareness about cannabis use and its potential mental health risks.
Sixty-one participants aged 18-35 participated in the study, with some having CUD and others diagnosed with first-episode schizophrenia. The researchers found that individuals with CUD exhibited increased dopamine activity in the substantia nigra and ventral tegmental areas, regions linked to psychosis.
The study’s findings have significant implications for understanding cannabis use disorder and psychosis. “We now have a clearer picture of how cannabis use affects the brain,” said lead researcher Lena Palaniyappan. The research underscores the need for safe and informed cannabis use policies to mitigate mental health risks.
The study’s authors hope that their findings will encourage further research and inform public health policies to support safe and informed cannabis use.
Source: https://neurosciencenews.com/cannabis-use-disorder-psychosis-28746/