Research published in The Lancet Healthy Longevity suggests that moderate-to-vigorous physical activity may not be enough to slow cognitive decline in older adults, especially those with high levels of tau proteins in their brains.
Tau proteins play a crucial role in regulating brain function and are linked to Alzheimer’s disease. Researchers investigated the relationship between physical activity, tau protein levels, and cognition in healthy older adults with memory complaints.
The study analyzed data from over 1,600 participants who were aged 70 or older and had self-reported memory complaints. The results showed that moderate-to-vigorous physical activity was associated with a slower increase in tau protein levels over time, but this association only applied to individuals who were inactive compared to active ones.
However, the researchers found no significant effect of physical activity on cognitive decline or changes in tau protein levels in those with low to moderate levels of physical activity. Furthermore, high levels of tau proteins attenuated the positive association between physical activity and cognition.
The study’s findings have implications for understanding the complex relationship between exercise, tau protein levels, and cognitive function. The researchers highlight the need for further studies to confirm these results and explore other factors that may influence the effects of physical activity on cognitive decline.
In summary, while moderate-to-vigorous physical activity may be beneficial for overall health, its impact on slowing cognitive decline in older adults with high tau protein levels is unclear. More research is needed to determine the optimal level and duration of exercise to prevent or slow down cognitive decline in this population.
Source: https://www.news-medical.net/news/20250226/Research-shows-exercise-can-delay-Alzheimere28099s-but-theree28099s-a-catch.aspx