A new study published recently sheds light on how physical activity helps protect the brain from Alzheimer’s disease at a cellular level. Researchers used single-nuclei RNA sequencing (snRNA-seq) to examine how exercise reshapes the brain in mouse models of Alzheimer’s disease.
The study focused on the hippocampus, a region responsible for making new memories and processing emotions. Scientists found that exercise changed activity in immune cells called NVAs, which help regulate oxygen supply to the brain. These cells play an important role in neuroprotection.
Researchers also identified a metabolic gene called ATPIF1, which regulates energy production in brain cells. Stimulating this gene may protect against Alzheimer’s disease.
Experts emphasize the importance of physical activity for brain health and say that exercise can remodel key cell types to increase their neuroprotective properties. While there is currently no cure for Alzheimer’s disease, lifestyle changes such as exercise may help decrease a person’s risk or slow down its progression.
Dr. Christiane D. Wrann, lead researcher on the study, notes that exercise can improve brain cells in Alzheimer’s disease, potentially rendering them more functional. The findings offer new insights into how exercise benefits the brain and could lead to future therapies for Alzheimer’s prevention and treatment.
Source: https://www.medicalnewstoday.com/articles/study-how-exercise-protects-brain-alzheimers-disease-aging