Researchers have successfully transplanted a lung from a genetically modified pig into a brain dead human recipient for the first time, with the lung functioning for nine days. This breakthrough is part of the growing field of xenotransplantation, which aims to address the global organ shortage crisis.
The study used a genetically modified pig’s left lung with six modifications, and the results showed that the lung remained viable and functional despite triggering an immune response. However, the transplant was complicated by fluid accumulation and damage, and the recipient’s immune system attacked the organ over time.
Experts emphasize that there is still much work to be done before xenotransplantation using pig lungs can become a viable treatment option. Dr. Justin Chan, a lung transplant surgeon, described the study as “exciting and promising” but noted that it was a single case study with limitations.
The researchers behind the study are calling for further refinement of their approach, including optimizing immunosuppressive regimens, refining genetic modifications, and enhancing lung preservation strategies. Other experts are exploring alternative approaches, such as using stem cells to remodel donor organs or growing humanized organs inside pigs.
While xenotransplantation for lungs holds promise, experts say that addressing the underlying causes of organ rejection is crucial to making this technology successful. With continued research and development, it may be possible to make significant progress in increasing the availability of organs and saving lives.
Source: https://www.theguardian.com/science/2025/aug/25/surgeons-transplant-pig-lung-into-brain-dead-human-recipient-for-first-time