A recent study has revealed that individuals with low levels of vitamin B12, even within the accepted “normal” range, are at a higher risk of neurological impairment and injury. Conducted by researchers from the University of California, San Francisco, the study utilized a multimodal testing approach to assess associations between B12 levels and markers of central nervous system (CNS) injury in older adults.
The research involved 231 healthy individuals aged 71 with median blood B12 concentration at 415 pmol/L. Analysis showed that low vitamin B12 levels were associated with slower conduction of nerve impulses, decreased spatial processing speed, and increased white matter hyperintensities (WMHs). Notably, the study found no correlation between total B12 levels and neurological symptoms.
The researchers believe that the high homocysteine levels secondary to B12 may be responsible for the neurological injury. While B12 supplementation often resolves hematological symptoms, it is not effective in reducing neurological symptoms associated with deficiency.
The findings emphasize the need for optimal B12 levels and call for a broader reconsideration of nutritional guidelines.
Source: https://www.news-medical.net/news/20250224/Normal-vitamin-B12-levels-may-not-prevent-brain-decline.aspx