A recent study published in the BMJ Journal of Neurology, Neurosurgery and Psychiatry has found that people with low levels of “bad” cholesterol, or LDL-C, may have a reduced risk of developing dementia. The study, which analyzed data from over 12 million people in South Korea, suggests that lowering LDL-C below 70 milligrams per deciliter (mg/dL) may be associated with a significant reduction in dementia risk.
Researchers found that those with LDL-C levels below 70 mg/dL had a 26% lower risk of all-cause dementia and a 28% lower risk of Alzheimer’s disease-related dementia compared to those with higher levels. The study also showed that statins, cholesterol-lowering medications, may further reduce the risk of dementia in people with low LDL-C.
However, experts caution that more research is needed to confirm these findings and establish causation. “The study reinforces the importance of lipid management in overall health, including cognitive function,” said Dr. Emer MacSweeney, a neuroradiologist at Re:Cognition Health. “But it also highlights the complexity of LDL-C’s role in dementia, suggesting that optimal levels exist rather than a ‘lower is always better’ approach.”
The study suggests that statins may have neuroprotective effects beyond simply lowering LDL-C, but more research is needed to confirm this association. The American Heart Association recommends keeping LDL-C levels below 100 mg/dL to reduce cardiovascular disease risk, and experts agree that maintaining healthy lifestyle habits, including a heart-healthy diet and regular physical activity, can also help protect against dementia.
Source: https://www.medicalnewstoday.com/articles/maintaining-low-cholesterol-may-help-decrease-dementia-risk