A Lufthansa Airbus A321 flew without a pilot in charge for 10 minutes on February 17, 2024, from Frankfurt to Seville after the co-pilot fainted in the cockpit. The incident was reported by Spanish investigators and confirmed by Lufthansa, which said its flight safety department conducted an internal investigation but did not disclose its findings. Fortunately, the aircraft continued to fly stably due to active autopilot, and the pilot regained control after completing emergency training. A voice recorder captured unusual noises in the cockpit during this time, consistent with a medical emergency.
Source: https://www.scmp.com/news/world/europe/article/3310779/lufthansa-plane-flown-autopilot-after-pilot-faints-cockpit