A man in his mid-70s has defied the odds by remaining symptom-free despite having a rare gene mutation that typically develops Alzheimer’s disease in people of similar age. The Oklahoma native, part of a large family afflicted with the condition, has sparked new hope among scientists for finding treatments.
According to researchers, the genetic variation affects a protein called amyloid and causes an early build-up of tau in the brain. However, this man’s scans show a healthier brain compared to his relatives, who have progressive memory loss. The discovery raises questions about the role of amyloid-tau interactions in Alzheimer’s development.
The “amyloid hypothesis” has dominated research for decades but recent studies suggest that both proteins may be involved. Current treatments mainly target amyloid, with limited success. This man’s case suggests a different approach might be necessary.
Researchers are now investigating possible factors that could have contributed to his protection, including an unusual job and differences in DNA compared to his relatives. The finding also highlights the importance of targeting tau when developing new treatments. While more research is needed, this breakthrough offers renewed optimism for an Alzheimer’s cure.
Source: https://inews.co.uk/news/science/people-cant-develop-alzheimers-cure-3539671