A breakthrough in weight loss treatment uses nanogels to deliver a synthetic thyroid hormone drug precisely to liver cells, bypassing systemic side effects. Researchers at the University of Massachusetts Amherst have successfully tested the treatment in mice, resulting in significant weight loss and improved cholesterol levels without harm.
For over 100 million Americans struggling with obesity and related metabolic disorders, finding effective treatments has been a challenge. A new discovery using nanogel technology offers hope for safer and more targeted therapies. Researchers designed the tiny carriers to deliver synthetic thyroid hormone drug axitirome specifically to liver cells, where it regulates metabolism and cholesterol levels.
The study showed promising results in mice, with treated animals losing weight and exhibiting improved cholesterol profiles despite consuming a high-fat diet. The findings suggest activating the reverse cholesterol transport pathway, which could lead to long-term solutions for obesity-related conditions.
The nanogel technology delivers axitirome by releasing it from its matrix once inside liver cells. This precise delivery avoids systemic side effects associated with traditional thyroid hormone treatments. While more work is needed to confirm these findings in humans, researchers are optimistic about the potential of this approach for treating metabolic diseases.
This breakthrough highlights the promise of nanogel technology for targeted drug delivery and may pave the way for further advancements in treating metabolic diseases.
Source: https://www.thebrighterside.news/health/lifesaving-drug-successfully-lowers-cholesterol-levels-and-body-weight